Air Greenland is operating Sisimiut. There are daily connections to and from Kangerlussuaq and Nuuk, and several weekly flights to and from Maniitsoq, Aasiaat and Ilulissat.
From Kangerlussuaq there are connections to Denmark with Air Greenland.
Umiaq Arctic Line A/S sailing Sisimiut two times a week during the summer.
In summer there is the opportunity to hike from Kangerlussuaq, and in winter can make the trip with either dog sled or snowmobile.
You can visit Arctic Circle Trail website for more informations about the hiking trail.